2 edition of factors affecting liquid and semi-solid mucoadhesion to the oral cavity and oesophagus found in the catalog.
factors affecting liquid and semi-solid mucoadhesion to the oral cavity and oesophagus
Simon A. Young
by University of Portsmouth, School of Pharmacy and Biomedical Sciences in Portsmouth
Written in English
Thesis (Ph.D.) - University of Portsmouth, 2000.
|Statement||Simon A. Young.|
In animal anatomy, the mouth, also known as the oral cavity, buccal cavity, or in Latin cavum oris, is the opening through which many animals take in food and issue vocal sounds. It is also the cavity lying at the upper end of the alimentary canal, bounded on the outside by the lips and inside by the pharynx and containing in higher vertebrates the tongue and teeth. Oral cavity. Oral cavity is basically same as the mouth and the cavity is made up of the cheeks, soft and hard palates and the lips which act as the vestibule for the oral cavity. Some of the other risk factors include Plummer-vision syndrome which is the mucosal atrophy of the mouth, pharynx and oesophagus, achlorhydria and iron deficiency.
it can severely affect nutrition and oxygenation, as well as speech, body image, and self-esteem -assess the oral cavity using nonsterile gloves; use adequate lighting and tongue blade -encourage liquids to thin saliva-oral hygiene every two hours. out that poor oral hygiene  and chronic periodontitis  may increase the risk of oral cancer. Numerous microorganisms, inhabiting in the oral region, such as bacteria, viruses and fungi, may affect the development and progression of OSCC. In this article, we describe the association of oral microorganisms and host-derived factors with.
The lining of the oral cavity is referred to as oral mucosa or oral mucous membrane. It is a stratified squamous epithelial arrangement that runs from the margins of the lips posteriorly to the area of the tonsils. Although this same epithelium is found posterior to this point, there it is part of the oral pharynx and not the oral cavity. The oral cavity is lined by a mucous membrane (the oral mucosa) consisting of a stratified squamous epithelium, which may or may not be keratinized, and an underlying connective tissue layer, the lamina propria. The surface is kept moist with mucus produced by the major and numerous minor salivary glands. The oral mucosa is well supplied with.
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The factors affecting liquid and semi-solid mucoadhesion to the oral cavity and oesophagus. Author: Young, Simon A. ISNI: Awarding Body: University of Portsmouth Current Institution: University of Portsmouth Date of Award. The factors affecting liquid and semi-solid mucoadhesion to the oral cavity and oesophagus.
Thesis (Thesis) Find all citations by this author (default).Cited by: 1. The factors affecting liquid and semi-solid mucoadhesion to the oral cavity and oesophagus By Simon A. Young, Brian Carpenter, T. Nevell and J. Smart No.
The oral cavity represents a challenging area to develop an effective drug delivery modelling. Factors affecting the Mucoadhesion through various physiological factors liquid improve ment. Mucoadhesion Oral cavity mucosa.
Before exploring the theories of mucoadhesion, a sound comprehension of the target mucosal tissue structure and characteristics is required. Mucosal tissues cover various organs, however since this review is concerned with the incorporation of mucoadhesives into food products, only the oral cavity will be Cited by: This review highlights the anatomy and structure of oral mucosa, mechanism and theories of mucoadhesion, factors affecting mucoadhesion, characteristics and properties of.
Oral Cavity. Both physical and chemical digestion begin in the mouth or oral cavity which is the point of entry of food into the digestive system. The food is broken into smaller particles by mastication, the chewing action of the teeth. All mammals have teeth and can chew their food to begin the process of physically breaking it down into.
The oral cavity is bounded by the teeth, tongue, hard palate, and soft palate. These structures make up the mouth and play a key role in the first step of digestion: ingestion. This is where the teeth and tongue work with salivary glands to break down food into small masses that can be swallowed, preparing them for the journey through the.
Oral cancer can occur anywhere in the orofacial complex but is most often found on the tongue, the tonsils and oropharynx, the gums, floor of the mouth, lips, cheek lining or the hard palate. While the disease can affect anyone, men are twice as likely to develop oral cancer as women.
Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems.
The introductory section describes the structure and physiology of various. Factors affecting oral infections Certain factors increase the risk for oral or periodontal disease. Each one of these risk factors is important and can be explained as given below: Smoking: Smoking can lead to many dental health problems such as bad breath, gum disease, oral cancer, etc.
It is a powerful risk factor for both cardiovascular. unlikely that the mucoadhesion process is the same for all cases and therefore it cannot be described by a single theory. In fact, all theories are relevant to identify the important process variables.
8, 15 Factors Affecting Mucoadhesion22,23,24,25,26 Polymer related factors. Since the early s the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. The various advantages associated with these systems made buccal drug delivery as a novel route of drug administration.
It prolongs the residence time of the dosage form at the site of application. These systems remain in close contact with the absorption tissue, the mucous membrane.
Mucoadhesion theories of polymer attachment, methods of measuring mucoadhesion, and factors affecting mucoadhesion are discussed in this chapter.
In addition, conventional polymers and pharmaceutical dosage forms used for various buccal drug delivery systems have been investigated with the help of recent studies. Poor oral hygiene and consequent oral cancer can destroy the integrity of this area. Oral cavity cancers are more common in males than in females, with a ratio of – The factors believed to cause oral cancer vary both geographically and culturally.
In India, cancer of the floor of the mouth accounts for 50 % of all cancers and 5 % of. Factors Affecting Mucoadhesion A. Polymer related factors a. Molecular weight b. Chain length c. Spatial arrangement d. Flexibility e. Hydration of polymer f. Hydrogen bonding g.
Polymer concentration B. Environmental factors a. pH b. Applied Strength c. Contact Time d. Swelling C. Physiological factors a. Mucin Turnover b. Disease State 3. The drug is not protected from the environment found in the oral cavity. 58 3. Liquid dosage form: • These are available in form of solution or suspension of drug in suitable vehicle.
• There are many liquid dosage forms that are available in market such as mouthwashes, mouth freshener, and are generally used for local delivery of drugs. Physiological factors influencing oral drug absorption.
The gastrointestinal tract is complex. Figure outlines some of the main structures involved in and key physiological parameters that affect oral drug absorption. In order to gain an insight into the numerous factors that can potentially influence the rate and extent of drug absorption into the systemic circulation, a schematic.
The oral microbial composition is capable of affecting the balance of the oral cavity; the interactions between the resident flora depend on local environmental changes and the host’s diet. The presence of nutritious flakes of epithelium and secretions makes the oral cavity a highly favorable environment for various bacteria.
Oral cavity. The oral cavity is situated anteriorly on the face, under the nasal cavities. It is bounded by a roof, a floor and lateral walls. Anteriorly it opens to the face through the oral fissure, while posteriorly the oral cavity communicates with the oropharynx through a narrow passage called the oropharyngeal isthmus (also termed the.
INTRODUCTION. It is estimated t patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC) in the United States each year (), and oral cavity cancer ranks among the top ten most prevalent malignancies affecting patients worldwide ().Squamous cell carcinoma is by far the most common histology found for tumors of the oral cavity.This book is designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically.
The oral mucosa is a unique collection of tissues that constitutes a highly active environment with its own unique.The oral cavity is in close proximity to the central nervous system (brain and autonomic nervous system), the hormone/ endocrine system (thyroid and pituitary or master gland), the immune system (tonsils) and one of the two points in the body which control the overall structural (base of the skull and first cervical vertebra) alignment.